Spinal Cord Injury Research

The ultimate goal of spinal cord injury research at Kessler Foundation is to develop ways for individuals with SCI to fully restore their pre-injury levels of function, activity, and quality of life.

  • Extracorporeal shockwave therapy on spacticity in SCI

    The purpose of this study is to evaluate the effectiveness of a new treatment for spasticity called extracorporeal shockwave therapy.

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  • Identification of New Biomarkers for Determining Risk of Lower Extremity Fracture during Exoskeleton-assisted Ambulation

    The purpose of this study is to determine the forces on the hips, knees, and ankle joints while participating in exoskeleton-assisted sit-to-stand training protocol as well as exoskeleton-assisted walking (EAW) in the ReWalk, Indego, and Ekso devices.

     

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  • Scale Up Trial of Project WOWII to Increase Exercise Among People with Spinal Cord Injury

    The purpose of this study is to look at the usefulness of an internet program called Workout on Wheels (WOWII) to promote exercise and health for people with chronic SCI.

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  • Using Eye-tracker Based Cognitive Assessments to Examine Cognitive Functions in Spinal Cord Injury

    The purpose of this study is to evaluate a new set of hands-free tasks that will assess an individual’s thinking skills

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  • Treatment of Bone Loss in Persons with Chronic Spinal Cord Injury

    The purpose of this study is to determine the usefulness of taking Romosozumab for 1 year compared to a placebo (salt solution) followed by 1 year of Denosumab in those who had a spinal cord injury longer than 3 years.

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  • Prevention of Bone Loss in Persons with Subacute Spinal Cord Injury

    The purpose of this study is to compare Romosozumab for 12 months followed by Denosumab for 12 months vs. 24 months of Denosumab in persons with spinal cord injury less than 6 months prior to enrollment.

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  • Brain Activity in People with Chronic Neuropathic Pain and SCI

    The purpose of this research study is to learn more about how patterns of brain activity change during different thinking tasks and how these changes relate to the intensity and unpleasantness of the neuropathic pain experienced. 

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  • Comparison of Two Web-based Interventions in Partner Caregivers of People with SCI

    The purpose of this research study is to compare the effect of two different types of group education and support programs for partner caregivers of people with SCI. 

    This study is completely remote and does not require in-person visits.

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  • Upper Extremity Wearable Robotic Orthosis on Improving Upper Extremity Motor Function and Activities of Daily Living in SCI

    The purpose of this study is to evaluate the usefulness of an upper extremity assistive device called MyoPro in improving upper extremity activities in people with incomplete SCI. 

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  • Safety and Efficacy of Brain-Computer Interface-based Electromagnetic Field Treatment in Chronic SCI

    The purpose of this study is to evaluate the efficacy and safety of a new stimulation treatment delivered by a device called BrainQ.

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  • Intermittent Hypoxia Therapy in SCI

    The purpose of this research study is to investigate the effects of upper limb training while breathing low oxygen on arm strength and function in people with SCI. 

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  • Comparing Drug Treatments for Neurogenic Detrusor Overactivity in SCI

    The purpose of this study is to determine the effectiveness and safety of "Mirabegron" compared to "Oxybutynin IR" for a condition called neurogenic detrusor overactivity in individuals with SCI .

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  • Developing a Shortened Cognitive Screen in SCI

    The purpose of this study is to investigate the effectiveness of a screening battery of thinking skills in the spinal cord injury population. Participants will complete hands-free questionnaires. 

    This study is completely remote and does not require in-person visits. 

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  • Testosterone Replacement Therapy and Electrical Stimulation in SCI

    The aim of this study is to understand what happens to muscle and bone in spinal cord injured males with low testosterone levels after 5 months of stand training with body weight support (BWS) and testosterone replacement therapy (TRT).

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  • Upper Extremity/Treadmill/Exoskeleton Training and Spinal Cord Stimulation in SCI

    The purpose of this research is to examine the effectiveness of back or spine stimulation while walking on a treadmill or walking over ground using an exoskeleton or on muscle activation while sitting on a chair.

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  • Improving SCI Rehab Interventions by Retraining the Brain in SCI Participants

    The purpose of this study is to investigate whether combining training of the affected upper limbs in patients with SCI with a noninvasive technique of brain stimulation called transcranial direct current stimulation (tDCS) can improve training outcomes.

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  • Equity and Quality in Assistive Technology for Individuals with SCI (EQUATE)

    Researchers are collecting information about types and frequency of wheelchair breakdowns and repairs using a smartphone app. The information collected will help researchers track the types of wheelchair failures to inform wheelchair users. 

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  • Examining Learning Performance in People with Spinal Cord Injury Using MRI

    The purpose of this research study is to learn about different types of memory abilities in people who have a spinal cord injury (SCI) and how those abilities relate to brain functioning. 

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  • Informing Identification of Neuropathic Pain Phenotypes in People with SCI

    This proposed study will provide data needed to design, fund, and conduct large-scale, multi-center studies that are needed to establish "neuropathic pain phenotypes," which are the different types of nerve pain people with SCI experience after injury.

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  • Cortical Control of Walking: Brain Plasticity Following Exoskeleton Training in Incomplete Spinal Cord Injury (iSCI)

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  • Ultrasound-Guided Treatments for Chronic Shoulder Pain in Wheelchair Users with Spinal Cord Injury

    The purpose of this study is to compare the effectiveness of two different treatments for chronic shoulder pain in people with spinal cord injury (SCI).

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