Identification of New Biomarkers for Determining Risk of Lower Extremity Fracture during Exoskeleton-assisted Ambulation

The purpose of this study is to determine the forces on the hips, knees, and ankle joints while participating in exoskeleton-assisted sit-to-stand training protocol as well as exoskeleton-assisted walking (EAW) in the ReWalk, Indego, and Ekso devices.


For more information about this study, please contact Christopher Cirnigliaro at

Actively Recruiting

The study consists of three specific aims that each participant may randomly be selected for if s/he meet the inclusion/exclusion criteria. Specific Aim 1 consists of 2 study visits. Specific Aim 2 consists of up to 10 study visits. Specific Aim 3 consists of up to 40 study visits.

Inclusion Criteria

Specific Aim 1, 2, and 3:

  1. I am between 18 and 70 years of age.
  2. I have a motor-complete or motor-incomplete SCI with a grade of A, B, or C according to the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI), [ formerly American Spinal Injury Association (ASIA) Impairment Scale].
  3. I am wheelchair dependent 100% of the time OR I am a healthy able-bodied male or female.

Specific Aim 2 (EAW Sit-to-Stand) and Aim 3 (EAW Walking) Only:

  1. The study staff has determined that I can fit into the walking device based on my weight and height.
  2. My weight is less than 220 lb.
  3. My height is between 62-75 in (5ft 2in – 6ft 3in)
  4. The study staff has determined that the T-score acquired by a bone density test (DXA)scan is greater than or equal to -3.1 OR my bone mineral density above the knee acquired by bone density test (DXA) is greater than or equal to 0.6 g/cm2
  5. I have adequate lower leg joint range of motion as determined by the study staff.
  6. I have a SCI and can commit for up to 10 sit-to-stand training sessions and up to 40 EAW training sessions OR I am an able-bodied control participant and can commit up to 3 sit-to-stand training sessions and up to 10 EAW training sessions.
  7. I can commit to 1 sit-to-stand motion analysis session and 3 EAW Sit-to-Stand walking motion analysis sessions.

Imaging Visit 1 (DXA, Peripheral quantitative computed tomography [pQCT]): $50

Imaging Visit 2 (computerized tomography (CT) scan): $50

Exoskeletal Sit-to-Stand Motion Capture Session: $100

EAW Motion Capture Session 1: $100

EAW Motion Capture Session 2: $100

EAW Motion Capture Session 3: $100

Research Categories
Healthy Volunteers
Spinal Cord Injury
IRB Number: