MS researchers determine that brain reserve independently protects against cognitive decline in MS
U.S. and Italian researchers have determined that brain reserve, as well as cognitive reserve, independently protects against cognitive decline in MS. Brain reserve and cognitive reserve in MS: What you’ve got and how you use it, was published June 11 in Neurology
West Orange, NJ. June 24, 2013. U.S. and Italian researchers have determined that brain reserve, as well as cognitive reserve, independently protects against cognitive decline in multiple sclerosis (MS). Their article, “Brain reserve and cognitive reserve in multiple sclerosis: What you’ve got and how you use it”, was published in Neurology on June 11, 2013 (Neurology 2013;80:2186-2193). Authors James Sumowski, PhD, Victoria Leavitt, PhD, and John DeLuca, PhD, are with Kessler Foundation in West Orange, NJ. Maria Rocca, MD, Gianna Riccitelli, PhD, Giancarlo Comi, MD, and Massimo Filippi, MD, are with San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
“Our research interests focus on why many people with MS suffer cognitive impairment, while others with MS withstand considerable disease progression without cognitive decline,” said Dr. DeLuca, VP for Research & Training at Kessler Foundation. “With our colleagues in Milan, we explore factors associated with lack of cognitive decline despite marked changes on imaging studies.” In this study, 62 patients with MS (41 relapsing-remitting MS, 21 secondary progressive MS) had MRIs to estimate brain reserve and disease burden. Early-life cognitive leisure was measured as a source of cognitive reserve. Cognitive status was measured with tasks of cognitive efficiency and memory.
Dr. Sumowski, principal author/ investigator, commented on the importance of the study, saying, “We demonstrated for the first time that larger maximal lifetime brain growth (which is heritable) and early life mental stimulation (e.g., reading, games, hobbies) independently and differentially protect against cognitive decline in MS. That is, genetics and life experience independently protect against cognitive decline in persons with MS.” Foundation scientists have previously documented the protective effect of intellectual enrichment in MS.
Dr. Sumowski is a research scientist in Neuropsychology & Neuroscience Research, under the directorship of Nancy Chiaravalloti, PhD. Drs. Sumowski, Leavitt and DeLuca are on the faculty of the department of physical medicine and rehabilitation at UMDNJ-New Jersey Medical School.
Relevant publications:
Sumowski JF, Wylie GR, Chiaravalloti N, DeLuca J. Intellectual enrichment lessens the effect of brain atrophy on learning and memory in multiple sclerosis. Neurology. 2010 Jun 15;74(24):1942-5.
Sumowski JF, Wylie GR, Leavitt VM, Chiaravalloti ND, DeLuca J. Default network activity is a sensitive and specific biomarker of memory in multiple sclerosis. Mult Scler. 2013 Feb;19(2):199-208.
About Neurology
Neurology® is the Official Journal of the American Academy of Neurology (AAN). As the leading clinical neurology journal worldwide, Neurology® is directed to physicians concerned with diseases and conditions of the nervous system. The journal's purpose is to advance the field by presenting new basic and clinical research with emphasis on knowledge that will influence the way neurology is practiced. The journal is at the forefront in disseminating cutting-edge, peer-reviewed information to the neurology community worldwide. Editorial content includes full-length Articles, Clinical/Scientific Notes, Views & Reviews (including Medical Hypothesis papers), Issues of Neurological Practice, Historical Neurology, NeuroImages, Humanities, Correspondence, Book Reviews, Software Reviews, Calendar Listings, and position papers from the American Academy of Neurology. Contents appearing solely online include the Resident and Fellow Page, selected NeuroImages, Patient Page, CME Quizzes, Podcasts, and supplementary data (including video) for specific articles. The online version is considered the canonical version of the journal because it includes all content available to the reader. Neurology® is indexed in Medline/Pubmed, Embase, Scopus, Biological Abstracts®, PsycINFO®, Current Contents®, and Web of Science®.
About MS Research at Kessler Foundation
Kessler Foundation's cognitive rehabilitation research in MS is funded by grants from the National Institutes of Health, National MS Society, Consortium of MS Centers, and Kessler Foundation. Under the leadership of John DeLuca, PhD, and Nancy Chiaravalloti, PhD, scientists in Neuropsychology & Neuroscience Research at Kessler Foundation have made important contributions to knowledge of cognitive decline in MS. Clinical studies span new learning, memory, executive function, attention and processing speed. Research tools include innovative applications of fMRI and virtual reality. Among recent findings are the benefits of cognitive reserve; correlation between cognitive performance and outdoor temperatures; the efficacy of short-term cognitive rehabilitation using modified story technique; and the correlation between memory improvement and cerebral activation on fMRI.
About Kessler Foundation
Kessler Foundation, a major nonprofit organization in the field of disability, is a global leader in rehabilitation research that seeks to improve cognition, mobility and long-term outcomes, including employment, for people with neurological disabilities caused by diseases and injuries of the brain and spinal cord. Kessler Foundation leads the nation in funding innovative programs that expand opportunities for employment for people with disabilities. For more information, visit KesslerFoundation.org.
Contacts:
Carolann Murphy, 973.324.8382, [email protected]
Lauren Scrivo, 973.324.8384, 973.768.6583 - c, [email protected]
