Thalamic atrophy moderates associations between aerobic fitness, and cognitive processing speed and walking endurance in MS

Aerobic exercise training promising for restoring function in individuals with multiple sclerosis-related thalamic atrophy.

Findings support the need to develop randomized controlled trials of aerobic exercise training in the subgroup presenting with biomarker of thalamic atrophy.

East Hanover, NJ. September 16, 2022. Thalamic atrophy needs to be considered in clinical studies of the functional abilities of individuals with multiple sclerosis, according to findings reported by a team of experts. The article, “Thalamic atrophy moderates associations among aerobic fitness, cognitive processing speed, and walking endurance,” was published in the Journal of Neurology on June 19, 2022 (doi: 10.1007/s00415-022-11205-9). Article link: https://link.springer.com/article/10.1007/s00415-022-11205-9.

The authors are Brian Sandroff, PhD, Cristina A.F. Román, PhD, Glenn R. Wylie, DPhil, and John DeLuca, PhD, of Kessler Foundation, Robert W. Motl, PhD, of the University of Illinois Chicago, Gary R. Cutter, MS, PhD, of the University of Alabama at Birmingham, and Ralph H.B. Benedict, PhD, Michael G. Dwyer III, PhD, and Robert Zivadinov, MD, PhD, of the University of Buffalo.

MS-related thalamic atrophy is a major biomarker for neurodegeneration and associated physical and cognitive decline, highlighting the importance of exploring ways to restore and maintain function in individuals who present with this consequence of the disease. Aerobic exercise training is one promising approach, but little is known about its potential effects in individuals who present with thalamic atrophy.

The team conducted a cross-sectional study to examine the associations among aerobic fitness, cognitive processing speed, and walking endurance in individuals with and without thalamic atrophy. Subjects comprised 44 fully ambulatory individuals with MS from three randomized controlled trials. Outcomes included aerobic fitness (peak oxygen consumption during graded treadmill exercise), processing speed (Symbol Digit Modalities Test), walking endurance (6-min walk test), and thalamic neuroimaging.

Results provided initial evidence for strong and selective associations among aerobic fitness, cognitive processing speed, and walking endurance in individuals with thalamic atrophy, according to lead author Dr. Sandroff. “This study suggests that aerobic exercise training has the potential to restore function in individuals with thalamic atrophy, who are clearly at risk for progressive physical and cognitive decline,” he stated. “To explore the impact on outcomes, we need to develop randomized controlled trials of aerobic exercise training in the subgroup presenting with thalamic atrophy.”   

Citation: Sandroff, B.M., Motl, R.W., Román, C.A.F. et al. Thalamic atrophy moderates associations among aerobic fitness, cognitive processing speed, and walking endurance in persons with multiple sclerosis. J Neurol 269, 5531–5540 (2022). https://doi.org/10.1007/s00415-022-11205-9 https://link.springer.com/article/10.1007/s00415-022-11205-9

Supported by EMD Serono, Inc., Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health under Award Number R01HD091155.