Kessler Foundation Press Releases


Researchers explore efficacy of methylphenidate for mental fatigue in multiple sclerosis

Pilot study at Kessler Foundation showed improvement in “state” mental fatigue with methylphenidate, but no effect on “trait” fatigue

East Hanover, NJ. December 17, 2021. A team of researchers at Kessler Foundation studied the effects of methylphenidate on mental fatigue in individuals with multiple sclerosis (MS). This is the first study to examine the psychostimulant’s effects on "state" vs "trait" mental fatigue in MS. The article, "Methylphenidate may improve mental fatigue in individual with multiple sclerosis: A pilot clinical trial,” (doi: 10.1016/j.msard.2021.103273) was published online on September 20, 2021, by Multiple Sclerosis and Related Disorders.
Link to abstract:

The majority of individuals with MS experience physical and mental fatigue, a symptom that adversely affects their quality of life and contributes to disability. Mental fatigue, which is attributed to dopamine imbalance, may occur over time (trait fatigue) or at a defined moment (state fatigue). Methylphenidate, a psychostimulant that blocks catecholamine reuptake, including dopamine, alleviates fatigue in traumatic brain injury, Parkinson disease, and other neurological conditions. Evidence for the efficacy of psychostimulants for MS-related fatigue is inconclusive.

To assess the efficacy of methylphenidate for MS-related mental fatigue, Foundation researchers conducted a double-blind, placebo-controlled, crossover randomized control trial. Twelve participants with self-reported mental fatigue were tested for trait and state fatigue at baseline, after 4 weeks of methylphenidate, and after 4 weeks of placebo.

“We found improvement in 'state' fatigue with methylphenidate, but no effect on 'trait' fatigue,” reported lead author Joman Natsheh, MD, PhD, research lead at Children’s Specialized Hospital and visiting scientist at Kessler Foundation.

The results suggest an important role for dopamine in MS-relates mental fatigue. “Understanding the neurochemical basis of fatigue is fundamental to developing effective treatments,” she added. “While the effect on 'state' fatigue is encouraging, further investigation is needed to explore the lack of effect on 'trait' in this study. Results may differ in studies with larger sample sizes, objective measures of fatigue, and extended duration of methylphenidate administration.”   

Funding: National Multiple Sclerosis Society (PP2280)

About Children's Specialized Hospital
Children's Specialized Hospital, an RWJBarnabas Health facility, is the nation's leading provider of inpatient and outpatient care for children from birth to 21 years of age facing special health challenges--from chronic illnesses and complex physical disabilities like brain and spinal cord injuries, to a full scope of developmental, behavioral, and mental health concerns. At 15 different New Jersey locations, our pediatric specialists partner with families to make our many innovative therapies and medical treatments more personalized and effective so each child can reach their full potential.

About Kessler Foundation

Kessler Foundation, a major nonprofit organization in the field of disability, is a global leader in rehabilitation research that seeks to improve cognition, mobility, and long-term outcomes, including employment, for people with neurological disabilities caused by diseases and injuries of the brain and spinal cord. Kessler Foundation leads the nation in funding innovative programs that expand opportunities for employment for people with disabilities.

For more information, or to interview an expert, contact Carolann Murphy:




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