Social Cognition and Neuroscience Laboratory
Helen M. Genova, PhD is the assistant director of Neuropsychology & Neuroscience Research at Kessler Foundation. She is currently using functional magnetic resonance imaging, magnetic resonance spectroscopy and diffusion tensor imaging to examine cognitive impairments in MS and TBI, and how these impairments relate to neuronal pathology. Dr. Genova has been awarded a grant from the National Multiple Sclerosis Society (NMSS) to apply neuroimaging techniques to the examination of cognitive fatigue in MS, as well as a pilot grant from the NMSS to examine longitudinal changes in white matter integrity and cognitive functioning in MS.
She is currently using functional magnetic resonance imaging, magnetic resonance spectroscopy and diffusion tensor imaging to examine cognitive impairments in MS and TBI, and how these impairments relate to neuronal pathology.
Examining cognitive dysfunction in various clinical and neurological populations including Obsessive Compulsive Disorder, Chronic Fatigue Syndrome, Multiple Sclerosis (MS) and Traumatic Brain Injury (TBI)
van Geest Q, Douw L, van 't Klooster S, Leurs CE, Genova HM, Wylie GR, Steenwijk MD, Killestein J, Geurts JJG, Hulst HE. (2018) Information processing speed in multiple sclerosis: Relevance of default mode network dynamics. Neuroimage Clin. 19:507-515. doi: 10.1016/j.nicl.2018.05.015. PubMed PMID: 29984159; PubMed Central PMCID: PMC6030565.
Akbar N, Sandroff BM, Wylie GR, Strober LB, Smith A, Goverover Y, Motl RW, DeLuca J, Genova H. (2018) Progressive resistance exercise training and changes in resting-state functional connectivity of the caudate in persons with multiple sclerosis and severe fatigue: A proof-of-concept study. Neuropsychol Rehabil. 1-13. doi: 10.1080/09602011.2018.1449758. PubMed PMID: 29618280.
Wylie GR, Dobryakova E, DeLuca J, Chiaravalloti N, Essad K, Genova H. (2017) cognitive fatigue in individuals with traumatic brain injury is associated with Caudate Activation. Sci Rep. 7(1):8973. doi: 10.1038/s41598-017-08846-6. PubMed PMID: 28827779; PubMed Central PMCID: PMC5567054.
Dobryakova E, Hulst HE, Spirou A, Chiaravalloti ND, Genova HM, Wylie GR, DeLuca J. (2017) Fronto-striatal Network activation leads to less fatigue in multiple sclerosis. Mult Scler. 24(9):1174-1182. doi: 10.1177/1352458517717087. Epub PubMed PMID: 28627957.
Wylie GR, Genova HM, DeLuca J, Dobryakova E. (2017) the relationship between outcome prediction and cognitive fatigue: a convergence of paradigms. Cogn Affect Behav Neurosci. 838-849. doi: 10.3758/s13415-017-0515-y. PubMed PMID: