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Improving Cognition in People with Progressive Multiple Sclerosis: A Multi-Arm Randomized Trial of Cognitive Rehabilitation and Physical Exercise

The purpose of this research is to study whether completing thinking exercises on a computer combined with physical exercise is an effective treatment for difficulties with thinking, memory, and problem-solving in individuals with Progressive Multiple Sclerosis (PMS).

Duration

Participation lasts approximately 9 months. Participants will complete initial baseline testing of thinking skills, physical fitness, and an optional fMRI scan. Participants are then randomly assigned to one of two training groups that meet twice a week for 12 weeks and complete short-term and long-term follow-up testing.

Inclusion Criteria
  • Individuals diagnosed with primary or secondary progressive MS.
  • Aged 25-60.
  • No other neurological disorders or disease (e.g. stroke, brain injury, epilepsy).
  • Individuals who do not use a wheelchair as their primary mode of transit.
Compensation

Participants who complete the study receive $225. Participants who qualify for the fMRI scans and decide to participate will receive an additional $75.

Research Categories
Multiple Sclerosis
Actively Recruiting
Yes