Neuromuscular and Electrophysiology Laboratory
Dr. Allexandre joined the Human Performance Engineering Lab at Kessler Foundation as a Research Scientist in 2012. Before coming to Kessler Foundation, Dr. Allexandre was a post-doctoral fellow in the department of Biomedical Engineering and Center of Integrative Medicine and Wellness Institute at the Cleveland Clinic, Cleveland, OH. His main background and expertise are in biomedical modeling, signal processing, neuroimaging and cardiac, muscle and brain electrophysiology.
Dr. Allexandre current interest focuses on two line of research areas: (1) mechanisms underlying neuromuscular function and impairment, and (2) psychophysiological effects of stress and benefit of mind body practices (relaxation, meditation, yoga). His laboratory uses a multidisciplinary approach involving structural and functional imaging (DTI, MRI, fMRI), electrophysiological techniques (ERP, EMG, ECG, EEG, TMS) and behavioral assessment, combined with advanced signal processing and analysis to better understand the brain-muscle-motor function and integration and psychosomatic effect of stress and mind-body practices.
In the area of neuromuscular impairment, Dr. Allexandre has been investigating central (brain) vs. peripheral (muscle) origin of motor fatigue in cancer patients. He is currently conducting research on the structural and functional changes related to psychomotor impairment following chemotherapy in breast cancer patients. In line with prior work on the potential benefit and mechanism of mental imagery in rehabilitation, he is a co-investigator in an NIH grant aimed at studying the benefit of high mental concentration/effort during physical exercise training in breast cancer patients with symptoms of weakness. Dr. Allexandre has recently been awarded a grant from the New Jersey Commission on Brain Injury Research to investigate the underlying neuromuscular mechanisms of balance deficit in Traumatic Brain Imaging (TBI).
In the area of psychophysiological effect of stress and benefits of mind-body practices, Dr. Allexandre has investigated benefit of relaxation in newly diagnosed prostate cancer patients as well as the benefit and underlying mechanisms of action of yoga and mindfulness meditation. He had also studied the benefit of web-based mindfulness program for stress management and well-being. He is currently looking at neural mechanisms by which mindfulness meditation improves attention and emotional regulation in TBI.
Allexandre, D., Fox E., Bena J., Rauch J., Kobe I., Fox, J.E.B. (2008) Effects of Guided Imagery on Heart Rate Variability, Cleveland Clinic Journal of Medicine; 75 (Suppl 2) S106
Allexandre D., Morledge T. and Fox J. E.B.(2008) Mindfulness, yoga, and cardiovascular disease, Cleveland Clinic Journal of Medicine; 75 (Suppl 2) S108.
Allexandre, D., Otani, N.F. (2004) Preventing alternans-induced spiral wave breakup in cardiac tissue: An ion-channel-based approach, Phys. Rev. E 70, 061903.
Allexandre, D.,Otani, N. F. (2002) Accuracy and Speed Considerations of a new numerical method for modeling cardiac excitation, Computers in Cardiology. 9-12.
Allexandre, D., Palmer, M.R. (1996) Limited Diffraction Beams from Cylindrical Arrays. IEEE Ultrasonics Symposium Proceedings. 2:1577-1580.