Didier Allexandre, PhD

head shot of Didier Allexandre

Senior Research Scientist

Laboratory
Neuromuscular and Electrophysiology Laboratory
Phone
973-324-3541

Dr. Allexandre is a senior research scientist in the Center for Mobility and Rehabilitation Engineering Research at Kessler Foundation and director of the Neuromuscular and Electrophysiology Laboratory. For more than 20 years, he has studied brain and muscle electrophysiology, biomedical signal processing, and neuroimaging, and is a principal investigator and co-investigator on several state and federally funded grants in rehabilitation engineering research. Dr. Allexandre is an assistant research professor in the Department of Physical Medicine & Rehabilitation at Rutgers – New Jersey Medical School.

Expertise
Electrophysiology
Neurorehabilitation
Neuroimaging
Signal Processing
Biomedical Modeling
Cancer rehabilitation
Brain stimulation
Education
PhD - Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
MA Sc - Electrical Engineering, University of British Columbia, Vancouver, Canada
BSc - General Engineering, Ecole Nationale Supérieure des Techniques Avancées, Paris, France
Honors
Trainee Travel Award, North American Research Conference on Complementary and Integrative Medicine Conference, 2009
Young Investigator Research Award, Bakken Heart Brain Institute Summit, Cleveland Clinic, 2007
Whitaker Fellowship, Case Western Reserve University, 2000
Rosanna Degani Young Investigator Award, International Computers in Cardiology, 1996
Research Interests

Dr. Allexandre focuses on two research areas: (1) mechanisms underlying neuromuscular function and impairment, and recovery, and (2) psychophysiological effects of stress and the benefits of mind-body practices (relaxation, meditation, yoga). His research is based on a multidisciplinary approach involving structural and functional imaging (DTI, MRI, fMRI), electrophysiological techniques (ERP, EMG, EEG, TMS), and behavioral assessment, combined with advanced signal processing and analysis (source-space EEG connectivity, independent component analysis, time-frequency analysis, graph-theory, multivariate correlation analysis, etc.).

In the area of neuromuscular impairment, Dr. Allexandre’s research aims at better understanding of motor control and deficits in various clinical populations including cancer, stroke and traumatic brain injury (TBI), as well as cortico-muscular mechanisms of recovery following novel interventions such as motor imagery, neurofeedback, neuromodulation and robot-assisted rehabilitation. More specifically, Dr. Allexandre has been investigating central (brain) vs. peripheral (muscle) origin of motor fatigue and the benefit of intense mental concentration/effort during physical exercise training in breast cancer patients with symptoms of cancer-related weakness. Dr Allexandre was the principal investigator on a New Jersey Commission on Brain Injury Research-sponsored research project aimed at better understanding the neural and electrophysiological mechanisms of balance related sensorimotor impairment in TBI and the benefit of a biofeedback balance intervention. Dr. Allexandre is also exploring ways to improve neuroplasticity and movement recovery using brain stimulation, neurofeedback, and robot-assisted rehabilitation training in spinal cord injury, stroke and TBI.

In the area of psychophysiological effects of stress and benefits of mind-body practices, Dr. Allexandre has investigated the benefits of relaxation, yoga, and mindfulness meditation, as well as the benefit of a web-based mindfulness program for stress management and well-being. He is currently looking at neural and neuropsychological mechanisms by which mindfulness meditation improves attention and emotional regulation in TBI, a project funded by the National Institute on Disability, Independent Living, and Rehabilitation Research.

Publications

View comprehensive listings of Dr. Allexandre’s publications on ResearchGate and GoogleScholar.

Podcasts
Memberships

Society for Neuroscience

Organization for Human Brain Mapping

IEEE Engineering in Medicine and Biology Society