Foundation Researchers Explore Role of Dopamine in MS fatigue

September 28, 2015. Scientists at Kessler Foundation authored a review article that describes a specific hypothesis for fatigue in multiple sclerosis (MS). “The dopamine imbalance hypothesis of fatigue in multiple sclerosis and other neurological disorders,” was published in the open access journal, Frontiers in Neurology (doi: 10.3389/fneur.2015.00052). This hypothesis builds upon evidence from studies in neuropsychology, pharmacology, immunology, and neuroimaging that point to a critical role for dopamine, a modulatory neurotransmitter. Authors Ekaterina Dobryakova, PhD, Helen Genova, PhD, John DeLuca, PhD, and Glenn Wylie, DPhil, recommend further investigation of the role of dopamine in fatigue.