Ekaterina Dobryakova

Ekaterina Dobryakova
Research Scientist

It is no exaggeration to say that motivated behavior and valuation of its outcomes is an integral part of daily life. The cortico-striatal brain network has been shown to play an important role in motivated behavior as well as in fatigue and depression that so many clinical populations experience, including individuals with traumatic brain injury and multiple sclerosis. Using functional neuroimaging, I investigate the functioning of the cortico-strital network during motivated behavior and its relationship with fatigue and depression. I also explore functional and effective brain connectivity in relationship with cognition in individuals with traumatic brain injury and multiple sclerosis. 

Follow Dr. Dobryakova on Twitter: @e_dobryakova

Read Dr. Dobryakova's recent articles on Huffington Post:

Read Dr. Dobryakova's recent American Congress of Rehabilitation Medicine (ACRM) newsletter articles:

In this lecture podcast Dr. Irene Ward of Kessler Institute for Rehabilitation introduces Dr. Ekaterina Dobryakova, of Kessler Foundation, presenting “New Developments in Treating Fatigue Following TBI.” 


In this MS & Me Research Radio show, Dr. Dobryakova discusses her study using functional neuroimaging to examine the prospect of monetary rewards to stimulate the frontostriatal network; resulting in the reduction of cognitive fatigue in individuals with MS and healthy controls.




Dobryakova E., Hulst, HH., Spirou, A., Chiaravalloti, ND., Genova, HM., Wylie, GR., DeLuca, J. (2017). Fronto-striatal network activation leads to less fatigue in multiple sclerosis. Multiple Sclerosis Journal, Epub.

Wylie GR, Genova HM, DeLuca J, Dobryakova E. (2017). The relationship between outcome prediction and cognitive fatigue: A convergence of paradigms. Cognitive, Affective and Behavioral Neuroscience, Epub.

Dobryakova, E., Rocca, M., Valsasina, P., DeLuca, J., and Filippi, M. (2017). Altered Neural Mechanisms Of Cognitive Control In Patients With Primary Progressive Multiple Sclerosis: An Effective Connectivity Study. Human Brain Mapping, 38, 2580-2588.

Dobryakova, E., Jessup, R.K., and Tricomi, E. (2017). Modulation of Ventral Striatal Activity by Subjective Cognitive Effort. NeuroImage, 147, 330-338. 

Dobryakova, E., Rocca, M., Valsasina, P., Ghezzi, A., Martinelli, V., Comi, G., DeLuca, J., Filippi, M. (2016). Abnormalities of the Executive Control Network in Multiple Sclerosis Phenotypes: An fMRI Effective Connectivity Study. Human Brain Mapping, 37(6), 2293-2304.

Huiskamp, M., Dobryakova, E., Wylie, GD., DeLuca, J., Chiaravalloti., ND. A Pilot Study of Changes in Functional Brain Activity during a Working Memory Task after mSMT Treatment: the MEMREHAB Trial (2016). Multiple Sclerosis and Related Disorders, 7, 76-82.

Marino, C., Dobryakova, E., Genova, HM., DeLuca, J. (2016). A Review of the Behavioral and Neural Correlates of Theory of Mind Following a Pediatric Traumatic Brain Injury. Brain Injury Professional, 12(4), 8-10.

Dobryakova, E., Costa, S.L., Wylie, G.R., DeLuca, J., Genova, H.M. (2016). Altered Effective Connectivity during the Processing Speed Task in Individuals with Multiple Sclerosis.  Journal of the International Neuropsychological Society, 22, 216-224.

Dobryakova, E., Genova, HM., DeLuca, J., Wylie, GR. (2015). The Dopamine Imbalance Hypothesis of Fatigue in Multiple Sclerosis and Other Neurological Disorders. Frontiers in NeurologySpecial Issue: Fatigue in Multiple Sclerosis, doi: 10.3389/fneur.2015.00052.

Chiaravalloti, N., Dobryakova, E., Wylie, G., DeLuca, J. (2015). Examining the Efficacy of the Cognitive Rehabilitation Technique in Persons with TBI using functional Magnetic Resonance Imaging (fMRI): The TBI-MEM Trial. Journal of Head Trauma and Rehabilitation, 30(4), 261-269.

Dobryakova, E., Boukrina, O., and Wylie, G.R. (2014). Investigation of Information Flow during a Novel Working Memory Task in Individuals with Traumatic Brain Injury. Brain Connectivity5 (7), 433-441.

Genova, H.M., Dobryakova, E., Gonen O., Hillary, F., Wylie, G., Wu, W.E., Inglese, M., Chiaravalloti, N., DeLuca, J. (2014). Examination of Functional Reorganization in Multiple Sclerosis using fMRI- Guided Magnetic Resonance Spectroscopy: A Pilot Study. Journal of Multiple Sclerosis, 2 (1), 1-6.


Dobryakova, E., Wylie, G., DeLuca, J., Chiaravalloti, N. (2014). A Pilot study Examining Functional Brain Activity 6 Months after Memory Retraining in MS: the MEMREHAB Trial. Brain Imaging and Behavior, Special Issue: Neuroimaging and Rehabilitation, 8 (3), 403-406.

Sandry, J., Genova, HM., Dobryakova, E., DeLuca, J., Wylie, G. (2014). Subjective Cognitive Fatigue in Multiple Sclerosis Depends on Task Length. Frontiers in NeurologySpecial Issue: Fatigue in Multiple Sclerosis, doi: 10.3389/fneur.2014.00214.


Dobryakova, E., Staffaroni, A., DeLuca, J., Sumowski, J. F., & Chiaravalloti, N., Wylie, G. R. (2014). CapMan:  a New Paradigm for Studying Working Memory. Brain Imaging and Behavior, 8 (4), 475-479.

Dobryakova, E., DeLuca, J., Genova, H., and Wylie, G. R. (2013). Neural Correlates of Cognitive Fatigue in Clinical Populations: Basal Ganglia and Cortico-Striatal Circuitry. Journal of International Neuropsychological Society, 19 (8), 849-853.

Dobryakova, E. and Tricomi, E. (2013).  Basal Ganglia Engagement during Feedback Processing after a Substantial Delay. Cognitive, Affective and Behavioral Neuroscience, 13 (4), 725-736.


Dobryakova, E., Rocca, M.A., & Filippi, M. (in press). Cerebral Re-Organization and Cognition in Multiple Sclerosis. In B. Sandroff and J. DeLuca, Cognition and Behavior in Multiple Sclerosis.

Marmarou, C.R., Parry, M.R., Dobryakova, E. (in press). Basal Ganglia. In J. Kreutzer, J. DeLuca, & B. Caplan, Encyclopedia of Clinical Neuropsychology.